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Emsisoft Emergency Toolkit has both a GUI and a command-line version, so you can scan your machine even if there are problems with the GUI.
With this toolkit, you not only get the malware scanner, you get Hi Jack Free and Blitz Blank as well.
VIPRE is run in safe mode and does not depend upon a GUI tool for use.
You double-click the executable and a command window opens with the scanner running (and running at blazing speeds).
I have found Sophos reliable enough to run even while the PC being scanned is in use.
Emsisoft Emergency Toolkit (Figure C) is a powerful malware removal tool that can scan for, and remove, more than six million dangers to your PC.
Clam Win doesn't offer a real-time scanner, but that's not an issue for a portable version. Sophos Anti Rootkit Portable (Figure B) is one of those tools you hope you never have to use— but you know, at some point, you will.
It will work on any machine with Power Shell v3 and greater.
Malwarebytes is no doubt one of the best anti-malware softwares available on the net – I have it as part of my default installation kit when I build/re-build a machine.
Should Spybot fubar your PC's registry, you'll have a backup to restore to, safe and sound.
You know that time is coming when you'll require the assistance of portable antivirus and/or anti-malware tool.
It's a shame that this is such a big part of the job, but it's inevitable.